Problem 7 The key region of a drug that is... [FREE SOLUTION] (2024)

Chapter 13: Problem 7

The key region of a drug that is critical for molecular recognition andbinding is which of the following? a allosteric site b affinity lattice c two-dimensional structure d amino acid sequence e pharmacophore.

Step by step solution

01

Understand the Question

Identify what the key region of a drug critical for molecular recognition and binding means. This refers to the specific part of a drug molecule that interacts directly with the target molecule, typically leading to a biological effect.

02

Define Each Option

Break down and define each of the given options:- Allosteric Site: A site on a protein that is not the primary active site but can bind a molecule to induce a conformational change in the protein.- Affinity Lattice: This term is not commonly used in the context of molecular recognition in biochemistry.- Two-Dimensional Structure: The planar or flat arrangement of atoms in a molecule, but it does not usually define binding specificity.- Amino Acid Sequence: The order of amino acids in a protein, which can determine protein folding and function, but it is more related to the structure of proteins rather than drugs.- Pharmacophore: The abstract description of molecular features required for molecular recognition of a ligand by a biological macromolecule.

03

Eliminate Incorrect Options

Disregard options that do not specifically refer to the part of a drug responsible for binding: - 'Affinity lattice' and 'two-dimensional structure' are not relevant for active binding region.- 'Amino acid sequence' is related to proteins, not directly to drugs.

04

Finalize the Answer

Evaluate the remaining options: - 'Allosteric site' is more specific to proteins and enzymes, indicating it's not the key region for binding but a secondary site.- 'Pharmacophore' is the correct term representing the part of the drug that binds to the target molecule relevant to molecular recognition.

Key Concepts

These are the key concepts you need to understand to accurately answer the question.

molecular recognition

In the world of biochemistry, molecular recognition is a term that refers to the specific interaction between two or more molecules through non-covalent bonding. Think of it as a lock and key mechanism where the molecules fit snugly together in a very specific way.
The 'key' refers to a drug or ligand, and the 'lock' is usually a biological macromolecule like a protein. Their interaction is highly specific and depends on the shape and chemical properties of both the drug and the target molecule. This precise interaction ensures that the drug's effect is specific and effective.

  • This leads to a biological response, like the activation or inhibition of an enzyme.
  • For the drug to be effective, it must correctly recognize and bind to the target molecule.
  • Any changes in the structure of the drug or the target can significantly affect the binding.

Understanding molecular recognition is crucial for designing effective drugs for various medical conditions.

pharmacophore

The concept of the pharmacophore is central to drug design and discovery. A pharmacophore is an abstract description of the essential features of a molecule necessary to ensure optimal interactions with a specific biological target. These features are critical for the molecule's biological activity.

  • It can include hydrogen bond donors and acceptors, aromatic rings, and charges.
  • These features are not necessarily connected by covalent bonds but are spatially arranged in a way that allows for effective binding to the target.
  • The pharmacophore helps researchers identify which parts of a molecule are critical for its interaction with its target.

This model allows scientists to modify existing drugs or design new ones by ensuring these essential features are present in the correct spatial arrangement.

biological macromolecule interaction

Biological macromolecules, such as proteins, nucleic acids, and polysaccharides, play crucial roles in biological processes. The interaction between these macromolecules and drug molecules is fundamental to triggering biological responses.
Interactions can occur through various non-covalent forces, including hydrogen bonds, ionic bonds, Van der Waals forces, and hydrophobic interactions.

  • Proteins are especially common targets for drugs because they are involved in almost all cellular processes.
  • The specific part of the macromolecule where the drug binds is known as the binding site.
  • Understanding the nature of these interactions helps in tailoring the drug's efficacy and reducing side effects.

Essentially, the interaction between biological macromolecules and drugs governs the therapeutic effectiveness of the drug and the body's response. This is why drug design requires a deep understanding of these interactions.

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Problem 7 The key region of a drug that is... [FREE SOLUTION] (2024)

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